I use Single Scan, Brightness cutoff, and turn off the options (Speckles/Smooth Corners/Optimize). I copy the image to the clipboard from Photoshop, paste it in Inkscape, then run Trace Bitmap. Which seems like a fair job to vectorize. Here's a (reduced res) result of scanning some line art with the ScanSnap: I want the 1200dpi due to my rule of thumb that Trace Bitmap. Unfortunately, it produces that as a PDF, so I have to load it into PhotoShop to either save it to a PNG or copy it to the clipboard for import to Inkscape. The product really needs little or no cleaning up if the artwork was clean, so no need to futz with levels and all that since the scanner has done a pretty good job of picking the threshold for black. It has a setting to scan at 1200dpi in B&W, producing a bitmap with a color depth of one bit, which is perfect for line art. Lately, I've been using a ScanSnap to scan in line art. With the slightly new UI, I here make myself another reminder. I'm working in pure black and white anyway, so that probably helps make trace bitmap appealing.

I also remind myself Inkscape's Path->Trace Bitmap. I periodically remind myself that Inkscape can vectorize at least as well as the commercial offerings I looked at.

Inkscape trace bitmap scans